The Microfluidic Blood-Brain Barrier

Year: 
2017
Ranking: 
Entrant
Artist: 
Max Nowak, Tyler Brown
Department: 
Chemical Engineering
Lab: 
Mitragotri/Helgeson Labs

Description

Top and side views of a microfluidic blood-brain barrier (BBB). Endothelial cells (yellow) line the side channel, forming the "barrier" part of the BBB while astrocytes (magenta) represent the "brain". Cyan spots are the nuclei of each individual cell.

Cells were grown in the microfluidic, then fixed and stained for actin. Image was collected via fluorescent confocal microscopy; Z-stacks with 30 slices each were taken for 25 different sections of the device and then stitched together. Image was enhanced slightly to aid visualization.

CSEP CNSI Schuller Lab UCSB